Our research group has had a long-standing interest in the synthesis of complex, biological active natural products (Schemes 1-2). Each target must possess a challenging structural motif(s) that is not well addressed by current synthetic strategy. In addition, we are looking for a broader question or interest presented by the molecule that can be uniquely addressed through synthesis. Selected examples of broader importance include developing compounds with promising biological activity against clinically relevant pathogenic bacteria and for treatment of cancer. This combination allows us to push the frontiers of organic chemistry while addressing the larger scientific issues. Currently, our synthetic efforts are focused on macrolides (mandelalides, isomandelalide, madeirolide A & amphidinolides), terpenes (steriodial furans & obtusanal) and alkaloids (lycopodium alkaloids).